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At the same time, ferroptosis research should be integrated with studies on other central pathological processes in PD, including mitochondrial dysfunction and neuroinflammation, to investigate the interplay among multiple cell death pathways and develop combinatorial neuroprotective and disease-modifying therapies

[5] Joshi PC, Guidot DM

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Current protocols extrapolate from individual compound profiles and mechanistic pharmacology

Methionine is an essential sulfur-containing amino acid (C5H11NO2S) that serves as a crucial precursor for S-adenosylmethionine (SAMe), a universal methyl donor involved in over 100 biochemical reactions, including the synthesis of carnitine, which is essential for fatty acid transport

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity